Ontology highlight
ABSTRACT:
SUBMITTER: Madireddi S
PROVIDER: S-EPMC4076583 | biostudies-literature | 2014 Jun
REPOSITORIES: biostudies-literature
Madireddi Shravan S Eun So-Young SY Lee Seung-Woo SW Nemčovičová Ivana I Mehta Amit Kumar AK Zajonc Dirk M DM Nishi Nozomu N Niki Toshiro T Hirashima Mitsuomi M Croft Michael M
The Journal of experimental medicine 20140623 7
Biologics to TNF family receptors are prime candidates for therapy of immune disease. Whereas recent studies have highlighted a requirement for Fcγ receptors in enabling the activity of CD40, TRAILR, and GITR when engaged by antibodies, other TNFR molecules may be controlled by additional mechanisms. Antibodies to 4-1BB (CD137) are currently in clinical trials and can both augment immunity in cancer and promote regulatory T cells that inhibit autoimmune disease. We found that the action of agoni ...[more]