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A 'clicked' tetrameric hydroxamic acid glycopeptidomimetic antagonizes sugar-lectin interactions on the cellular level.

ABSTRACT: A tetrameric N-acetyl galactosaminyl (GalNAc) peptidomimetic was constructed by N-acetylation of repeating proline-based hydroxamic acid units, followed by a convergent 'click chemistry' coupling. This novel glycopeptidomimetic was determined to effectively antagonize the interaction between a transmembrane hepatic lectin and GalNAc on the cellular level.

SUBMITTER: Zhang HL

PROVIDER: S-EPMC4076733 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature

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A 'clicked' tetrameric hydroxamic acid glycopeptidomimetic antagonizes sugar-lectin interactions on the cellular level.

Zhang Hai-Lin HL Zang Yi Y Xie Juan J Li Jia J Chen Guo-Rong GR He Xiao-Peng XP Tian He H

Scientific reports 20140701

A tetrameric N-acetyl galactosaminyl (GalNAc) peptidomimetic was constructed by N-acetylation of repeating proline-based hydroxamic acid units, followed by a convergent 'click chemistry' coupling. This novel glycopeptidomimetic was determined to effectively antagonize the interaction between a transmembrane hepatic lectin and GalNAc on the cellular level. ...[more]

PMID: 24981800

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