Sildenafil increases muscle protein synthesis and reduces muscle fatigue.
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ABSTRACT:
SUBMITTER: Sheffield-Moore M
PROVIDER: S-EPMC4076819 | biostudies-literature | 2013 Dec
REPOSITORIES: biostudies-literature
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Sildenafil increases muscle protein synthesis and reduces muscle fatigue.
Sheffield-Moore Melinda M Wiktorowicz John E JE Soman Kizhake V KV Danesi Christopher P CP Kinsky Michael P MP Dillon Edgar L EL Randolph Kathleen M KM Casperson Shannon L SL Gore Dennis C DC Horstman Astrid M AM Lynch James P JP Doucet Barbara M BM Mettler Joni A JA Ryder Jeffrey W JW Ploutz-Snyder Lori L LL Hsu Jean W JW Jahoor Farook F Jennings Kristofer K White Gregory R GR McCammon Susan D SD Durham William J WJ
Clinical and translational science 20131029 6
Reductions in skeletal muscle function occur during the course of healthy aging as well as with bed rest or diverse diseases such as cancer, muscular dystrophy, and heart failure. However, there are no accepted pharmacologic therapies to improve impaired skeletal muscle function. Nitric oxide may influence skeletal muscle function through effects on excitation-contraction coupling, myofibrillar function, perfusion, and metabolism. Here we show that augmentation of nitric oxide-cyclic guanosine m ...[more]
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