Ontology highlight
ABSTRACT:
SUBMITTER: Myslinski JM
PROVIDER: S-EPMC4077163 | biostudies-literature | 2014 Jul
REPOSITORIES: biostudies-literature
Myslinski James M JM Clements John H JH Martin Stephen F SF
Bioorganic & medicinal chemistry letters 20140509 14
In order to probe the energetics associated with a putative cation-π interaction, thermodynamic parameters are determined for complex formation between the Grb2 SH2 domain and tripeptide derivatives of RCO-pTyr-Ac6c-Asn wherein the R group is varied to include different alkyl, cycloalkyl, and aryl groups. Although an indole ring is reputed to have the strongest interaction with a guanidinium ion, binding free energies, ΔG°, for derivatives of RCO-pTyr-Ac6c-Asn bearing cyclohexyl and phenyl group ...[more]