Ontology highlight
ABSTRACT:
SUBMITTER: Troy A
PROVIDER: S-EPMC4077199 | biostudies-literature | 2012 Oct
REPOSITORIES: biostudies-literature
Troy Andrew A Cadwallader Adam B AB Fedorov Yuri Y Tyner Kristina K Tanaka Kathleen Kelly KK Olwin Bradley B BB
Cell stem cell 20121001 4
In response to muscle injury, satellite cells activate the p38α/β MAPK pathway to exit quiescence, then proliferate, repair skeletal muscle, and self-renew, replenishing the quiescent satellite cell pool. Although satellite cells are capable of asymmetric division, the mechanisms regulating satellite cell self-renewal are not understood. We found that satellite cells, once activated, enter the cell cycle and a subset undergoes asymmetric division, renewing the satellite cell pool. Asymmetric loc ...[more]