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Stereoselective synthesis of carbocyclic analogues of the nucleoside Q precursor (PreQ0).

ABSTRACT: A convergent and stereoselective synthesis of chiral cyclopentyl- and cyclohexylamine derivatives of nucleoside Q precursor (PreQ0) has been accomplished. This synthetic route allows for an efficient preparation of 4-substituted analogues with interesting three-dimensional character, including chiral cyclopentane-1,2-diol and -1,2,3-triol derivatives. This unusual substitution pattern provides a useful starting point for the discovery of novel bioactive molecules.

SUBMITTER: Llona-Minguez S

PROVIDER: S-EPMC4077357 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature

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Stereoselective synthesis of carbocyclic analogues of the nucleoside Q precursor (PreQ0).

Llona-Minguez Sabin S Mackay Simon P SP

Beilstein journal of organic chemistry 20140611

A convergent and stereoselective synthesis of chiral cyclopentyl- and cyclohexylamine derivatives of nucleoside Q precursor (PreQ0) has been accomplished. This synthetic route allows for an efficient preparation of 4-substituted analogues with interesting three-dimensional character, including chiral cyclopentane-1,2-diol and -1,2,3-triol derivatives. This unusual substitution pattern provides a useful starting point for the discovery of novel bioactive molecules. ...[more]

PMID: 24991286

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