Ontology highlight
ABSTRACT:
SUBMITTER: Komrskova P
PROVIDER: S-EPMC4077738 | biostudies-literature | 2014
REPOSITORIES: biostudies-literature
PloS one 20140701 7
Regulation of mRNA translation by cytoplasmic polyadenylation is known to be important for oocyte maturation and further development. This process is generally controlled by phosphorylation of cytoplasmic polyadenylation element binding protein 1 (CPEB1). The aim of this study is to determine the role of Aurora kinase A in CPEB1 phosphorylation and the consequent CPEB1-dependent polyadenylation of maternal mRNAs during mammalian oocyte meiosis. For this purpose, we specifically inhibited Aurora ...[more]