Ontology highlight
ABSTRACT:
SUBMITTER: Abel HJ
PROVIDER: S-EPMC4078366 | biostudies-literature | 2014 Jul
REPOSITORIES: biostudies-literature
Abel Haley J HJ Al-Kateb Hussam H Cottrell Catherine E CE Bredemeyer Andrew J AJ Pritchard Colin C CC Grossmann Allie H AH Wallander Michelle L ML Pfeifer John D JD Lockwood Christina M CM Duncavage Eric J EJ
The Journal of molecular diagnostics : JMD 20140509 4
The identification of recurrent gene rearrangements in the clinical laboratory is the cornerstone for risk stratification and treatment decisions in many malignant tumors. Studies have reported that targeted next-generation sequencing assays have the potential to identify such rearrangements; however, their utility in the clinical laboratory is unknown. We examine the sensitivity and specificity of ALK and KMT2A (MLL) rearrangement detection by next-generation sequencing in the clinical laborato ...[more]