Ontology highlight
ABSTRACT:
SUBMITTER: Sharif EU
PROVIDER: S-EPMC4078405 | biostudies-literature | 2014 Jan
REPOSITORIES: biostudies-literature
Sharif Ehesan U EU Wang Hua-Yu Leo HY Akhmedov Novruz G NG O'Doherty George A GA
Organic letters 20131219 2
The first synthesis of the purported structure of Merremoside D has been achieved in 22 longest linear steps. The de novo asymmetric synthesis relied on the use of asymmetric catalysis to selectively install all 21 stereocenters in the final compounds from commercially available achiral starting materials. Adiabatic gradient 2D NMR techniques (gHSQCAD, gHMBCAD, gH2BCAD, gHSQCTOXYAD, ROESYAD) were used to completely assign the structure of synthetic Merremoside D. Comparison of our assignments wi ...[more]