Operon prediction by comparative genomics: an application to the Synechococcus sp. WH8102 genome.

ABSTRACT: We present a computational method for operon prediction based on a comparative genomics approach. A group of consecutive genes is considered as a candidate operon if both their gene sequences and functions are conserved across several phylogenetically related genomes. In addition, various supporting data for operons are also collected through the application of public domain computer programs, and used in our prediction method. These include the prediction of conserved gene functions, promoter motifs and terminators. An apparent advantage of our approach over other operon prediction methods is that it does not require many experimental data (such as gene expression data and pathway data) as input. This feature makes it applicable to many newly sequenced genomes that do not have extensive e

SUBMITTER: Chen X 

PROVIDER: S-EPMC407844 | biostudies-literature | 2004

REPOSITORIES: biostudies-literature