Ontology highlight
ABSTRACT:
SUBMITTER: Sage EK
PROVIDER: S-EPMC4078753 | biostudies-literature | 2014 Jul
REPOSITORIES: biostudies-literature
Sage Elizabeth K EK Kolluri Krishna K KK McNulty Katrina K Lourenco Sofia Da Silva Sda S Kalber Tammy L TL Ordidge Katherine L KL Davies Derek D Gary Lee Y C YC Giangreco Adam A Janes Sam M SM
Thorax 20140224 7
Malignant pleural mesothelioma is a rare but devastating cancer of the pleural lining with no effective treatment. The tumour is often diffusely spread throughout the chest cavity, making surgical resection difficult, while systemic chemotherapy offers limited benefit. Bone marrow-derived mesenchymal stem cells (MSCs) home to and incorporate into tumour stroma, making them good candidates to deliver anticancer therapies. Tumour necrosis factor-related apoptosis-inducing ligand (TRAIL) is a pro-a ...[more]