Ontology highlight
ABSTRACT:
SUBMITTER: Saito N
PROVIDER: S-EPMC4078760 | biostudies-literature | 2014 Jun
REPOSITORIES: biostudies-literature
Molecular therapy. Nucleic acids 20140610
MazF, an endoribonuclease encoded by Escherichia coli, specifically cleaves the ACA (adenine-cytosine-adenine) sequence of single-stranded RNAs. Conditional expression of MazF under the control of the HIV-1 LTR promoter rendered CD4(+) T cells resistant to HIV-1 replication without affecting cell growth. To investigate the safety, persistence and efficacy of MazF-modified CD4(+) T cells in a nonhuman primate model in vivo, rhesus macaques were infected with a pathogenic simian/human immunodefici ...[more]