Ontology highlight
ABSTRACT:
SUBMITTER: Luo X
PROVIDER: S-EPMC4079008 | biostudies-literature | 2014 May
REPOSITORIES: biostudies-literature
Luo Xi X Mitra Devarati D Sullivan Ryan J RJ Wittner Ben S BS Kimura Anya M AM Pan Shiwei S Hoang Mai P MP Brannigan Brian W BW Lawrence Donald P DP Flaherty Keith T KT Sequist Lecia V LV McMahon Martin M Bosenberg Marcus W MW Stott Shannon L SL Ting David T DT Ramaswamy Sridhar S Toner Mehmet M Fisher David E DE Maheswaran Shyamala S Haber Daniel A DA
Cell reports 20140418 3
Melanoma is an invasive malignancy with a high frequency of blood-borne metastases, but circulating tumor cells (CTCs) have not been readily isolated. We adapted microfluidic CTC capture to a tamoxifen-driven B-RAF/PTEN mouse melanoma model. CTCs were detected in all tumor-bearing mice and rapidly declined after B-RAF inhibitor treatment. CTCs were shed early from localized tumors, and a short course of B-RAF inhibition following surgical resection was sufficient to dramatically suppress distant ...[more]