Dataset Information

Stratification of risk of early-onset sepsis in newborns ? 34 weeks' gestation.

ABSTRACT:

Objective

To define a quantitative stratification algorithm for the risk of early-onset sepsis (EOS) in newborns ? 34 weeks' gestation.

Methods

We conducted a retrospective nested case-control study that used split validation. Data collected on each infant included sepsis risk at birth based on objective maternal factors, demographics, specific clinical milestones, and vital signs during the first 24 hours after birth. Using a combination of recursive partitioning and logistic regression, we developed a risk classification scheme for EOS on the derivation dataset. This scheme was then applied to the validation dataset.

Results

Using a base population of 608,014 live births ? 34 weeks' gestation at 14 hospitals between 1993 and 2007, we identified all 350 EOS cases <72 hours of age and frequency matched them by hospital and year of birth to 1063 controls. Using maternal and neonatal data, we defined a risk stratification scheme that divided the neonatal population into 3 groups: treat empirically (4.1% of all live births, 60.8% of all EOS cases, sepsis incidence of 8.4/1000 live births), observe and evaluate (11.1% of births, 23.4% of cases, 1.2/1000), and continued observation (84.8% of births, 15.7% of cases, incidence 0.11/1000).

Conclusions

It is possible to combine objective maternal data with evolving objective neonatal clinical findings to define more efficient strategies for the evaluation and treatment of EOS in term and late preterm infants. Judicious application of our scheme could result in decreased antibiotic treatment in 80,000 to 240,000 US newborns each year.

SUBMITTER: Escobar GJ

PROVIDER: S-EPMC4079292 | biostudies-literature | 2014 Jan

REPOSITORIES: biostudies-literature

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Publications

Stratification of risk of early-onset sepsis in newborns ≥ 34 weeks' gestation.

Escobar Gabriel J GJ Puopolo Karen M KM Wi Soora S Turk Benjamin J BJ Kuzniewicz Michael W MW Walsh Eileen M EM Newman Thomas B TB Zupancic John J Lieberman Ellice E Draper David D

Pediatrics 20131223 1

<h4>Objective</h4>To define a quantitative stratification algorithm for the risk of early-onset sepsis (EOS) in newborns ≥ 34 weeks' gestation.<h4>Methods</h4>We conducted a retrospective nested case-control study that used split validation. Data collected on each infant included sepsis risk at birth based on objective maternal factors, demographics, specific clinical milestones, and vital signs during the first 24 hours after birth. Using a combination of recursive partitioning and logistic reg ...[more]

PMID: 24366992

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