Ontology highlight
ABSTRACT:
SUBMITTER: Ycart B
PROVIDER: S-EPMC4079557 | biostudies-literature | 2014
REPOSITORIES: biostudies-literature
Ycart Bernard B Veziris Nicolas N
PloS one 20140702 7
Estimation methods for mutation rates (or probabilities) in Luria-Delbrück fluctuation analysis usually assume that the final number of cells remains constant from one culture to another. We show that this leads to systematically underestimate the mutation rate. Two levels of information on final numbers are considered: either the coefficient of variation has been independently estimated, or the final number of cells in each culture is known. In both cases, unbiased estimation methods are propos ...[more]