Ontology highlight
ABSTRACT:
SUBMITTER: Macintyre AN
PROVIDER: S-EPMC4079750 | biostudies-literature | 2014 Jul
REPOSITORIES: biostudies-literature
Macintyre Andrew N AN Gerriets Valerie A VA Nichols Amanda G AG Michalek Ryan D RD Rudolph Michael C MC Deoliveira Divino D Anderson Steven M SM Abel E Dale ED Chen Benny J BJ Hale Laura P LP Rathmell Jeffrey C JC
Cell metabolism 20140612 1
CD4 T cell activation leads to proliferation and differentiation into effector (Teff) or regulatory (Treg) cells that mediate or control immunity. While each subset prefers distinct glycolytic or oxidative metabolic programs in vitro, requirements and mechanisms that control T cell glucose uptake and metabolism in vivo are uncertain. Despite expression of multiple glucose transporters, Glut1 deficiency selectively impaired metabolism and function of thymocytes and Teff. Resting T cells were norm ...[more]