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The impact of hospital-onset Clostridium difficile infection on outcomes of hospitalized patients with sepsis.

ABSTRACT: To examine the impact of hospital-onset Clostridium difficile infection (HOCDI) on the outcomes of patients with sepsis.Most prior studies that have addressed this issue lacked adequate matching to controls, suffered from small sample size, or failed to consider time to infection.Retrospective cohort study.We identified adults with a principal or secondary diagnosis of sepsis who received care at 1 of the institutions that participated in a large multihospital database between July 1, 2004 and December 31, 2010. Among eligible patients with sepsis, we identified patients who developed HOCDI during their hospital stay.We used propensity matching and date of diagnosis to match cases to patients without Clostridium difficile infections and compared outcomes between the 2 groups.Of 218,915 sepsis patients, 2368 (1.08%) developed HOCDI. Unadjusted in-hospital mortality was significantly higher in HOCDI patients than controls (25% vs 10%, P?

SUBMITTER: Lagu T 

PROVIDER: S-EPMC4079761 | biostudies-literature | 2014 Jul

REPOSITORIES: biostudies-literature

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The impact of hospital-onset Clostridium difficile infection on outcomes of hospitalized patients with sepsis.

Lagu Tara T   Stefan Mihaela S MS   Haessler Sarah S   Higgins Thomas L TL   Rothberg Michael B MB   Nathanson Brian H BH   Hannon Nicholas S NS   Steingrub Jay S JS   Lindenauer Peter K PK  

Journal of hospital medicine 20140409 7

<h4>Objective</h4>To examine the impact of hospital-onset Clostridium difficile infection (HOCDI) on the outcomes of patients with sepsis.<h4>Background</h4>Most prior studies that have addressed this issue lacked adequate matching to controls, suffered from small sample size, or failed to consider time to infection.<h4>Design</h4>Retrospective cohort study.<h4>Setting and patients</h4>We identified adults with a principal or secondary diagnosis of sepsis who received care at 1 of the institutio  ...[more]

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