Ontology highlight
ABSTRACT:
SUBMITTER: Schwarzer R
PROVIDER: S-EPMC4080208 | biostudies-literature | 2014 Jun
REPOSITORIES: biostudies-literature
Schwarzer R R Nickel N N Godau J J Willie B M BM Duda G N GN Schwarzer R R Cirovic B B Leutz A A Manz R R Bogen B B Dörken B B Jundt F F
Blood cancer journal 20140613
Despite evidence that deregulated Notch signalling is a master regulator of multiple myeloma (MM) pathogenesis, its contribution to myeloma bone disease remains to be resolved. Notch promotes survival of human MM cells and triggers human osteoclast activity in vitro. Here, we show that inhibition of Notch through the γ-secretase inhibitor XII (GSI XII) induces apoptosis of murine MOPC315.BM myeloma cells with high Notch activity. GSI XII impairs murine osteoclast differentiation of receptor acti ...[more]