Ontology highlight
ABSTRACT:
SUBMITTER: Kang TW
PROVIDER: S-EPMC4080225 | biostudies-literature | 2014
REPOSITORIES: biostudies-literature
Kang Tae-Wook TW Choi Soon Won SW Yang Se-Ran SR Shin Tae-Hoon TH Kim Hyung-Sik HS Yu Kyung-Rok KR Hong In-Sun IS Ro Seonggu S Cho Joong Myung JM Kang Kyung-Sun KS
Scientific reports 20140703
Glioblastoma multiforme is the most common malignant brain tumor in adults, with an average survival of less than one year due to its resistance to therapy. Recent studies reported that GBM initiates from CD133-expressing cancer stem cells (CSC). However, the efficacy of CSC targeting is limited. A newly developed approach in cancer treatment is the forced differentiation of cancer cells. Here, we show that the treatment of the novel small molecule, CG500354, into CD133-expressing human primary ...[more]