Ontology highlight
ABSTRACT:
SUBMITTER: Gutierrez-Aguilar M
PROVIDER: S-EPMC4080311 | biostudies-literature | 2014 Jul
REPOSITORIES: biostudies-literature
Gutiérrez-Aguilar Manuel M Douglas Diana L DL Gibson Anne K AK Domeier Timothy L TL Molkentin Jeffery D JD Baines Christopher P CP
Journal of molecular and cellular cardiology 20140421
The Mitochondrial Permeability Transition (MPT) pore is a voltage-sensitive unselective channel known to instigate necrotic cell death during cardiac disease. Recent models suggest that the isomerase cyclophilin D (CypD) regulates the MPT pore by binding to either the F0F1-ATP synthase lateral stalk or the mitochondrial phosphate carrier (PiC). Here we confirm that CypD, through its N-terminus, can directly bind PiC. We then generated cardiac-specific mouse strains overexpressing or with decreas ...[more]