Immunomodulatory activity of orphan drug Elmiron® in female B6C3F1/N mice.
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ABSTRACT:
SUBMITTER: Thakur SA
PROVIDER: S-EPMC4080314 | biostudies-literature | 2014 Jun
REPOSITORIES: biostudies-literature
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Immunomodulatory activity of orphan drug Elmiron® in female B6C3F1/N mice.
Thakur Sheetal A SA Nyska Abraham A White Kimber L KL Smith Matthew J MJ Auttachoat Wimolnut W Germolec Dori R DR
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20140320
Interstitial cystitis (IC) is a chronic disorder characterized by bladder discomfort and urinary urgency in the absence of identifiable infection. Despite the expanding use in IC treatment and other chronic conditions, the effects of Elmiron® treatment on immune system remain unknown. Therefore, female B6C3F1/N mice were orally administered Elmiron® daily for 28-days at doses of 63, 125, 250, 500 or 1000mg/kg to evaluate its immunomodulatory effects. Mice treated with Elmiron® had a significant ...[more]
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