Healthy individuals treated with clomipramine: an fMRI study of brain activity during autobiographical recall of emotions.

ABSTRACT: Various functional magnetic resonance imaging studies addressed the effects of antidepressant drugs on brain functioning in healthy subjects; however, none specifically investigated positive mood changes to antidepressant drug. Sixteen subjects with no personal or family history of psychiatric disorders were selected from an ongoing 4-week open trial of small doses of clomipramine. Follow-up interviews documented clear positive treatment effects in six subjects, with reduced irritability and tension in social interactions, improved decision making, higher self-confidence and brighter mood. These subjects were then included in a placebo-controlled confirmatory trial and were scanned immediately after 4 weeks of clomipramine use and again 4 weeks after the last dose of clomipramine. The func

SUBMITTER: Cerqueira CT 

PROVIDER: S-EPMC4080327 | biostudies-literature | 2014 Jul

REPOSITORIES: biostudies-literature