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Feline fecal virome reveals novel and prevalent enteric viruses.

ABSTRACT: Humans keep more than 80 million cats worldwide, ensuring frequent exposure to their viruses. Despite such interactions the enteric virome of cats remains poorly understood. We analyzed a fecal sample from a single healthy cat from Portugal using viral metagenomics and detected five eukaryotic viral genomes. These viruses included a novel picornavirus (proposed genus "Sakobuvirus") and bocavirus (feline bocavirus 2), a variant of feline astrovirus 2 and sequence fragments of a highly divergent feline rotavirus and picobirnavirus. Feline sakobuvirus A represents the prototype species of a proposed new genus in the Picornaviridae family, distantly related to human salivirus and kobuvirus. Feline astroviruses (mamastrovirus 2) are the closest known relatives of the classic human astroviruses (mamastrovirus 1), suggestive of past cross-species transmission. Presence of these viruses by PCR among Portuguese cats was detected in 13% (rotavirus), 7% (astrovirus), 6% (bocavirus), 4% (sakobuvirus), and 4% (picobirnavirus) of 55 feline fecal samples. Co-infections were frequent with 40% (4/10) of infected cats shedding more than one of these five viruses. Our study provides an initial description of the feline fecal virome indicating a high level of asymptomatic infections. Availability of the genome sequences of these viruses will facilitate future tropism and feline disease association studies.

SUBMITTER: Ng TF

PROVIDER: S-EPMC4080910 | biostudies-literature | 2014 Jun

REPOSITORIES: biostudies-literature

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Feline fecal virome reveals novel and prevalent enteric viruses.

Ng Terry Fei Fan TF Mesquita João Rodrigo JR Nascimento Maria São José MS Kondov Nikola O NO Wong Walt W Reuter Gábor G Knowles Nick J NJ Vega Everardo E Esona Mathew D MD Deng Xutao X Vinjé Jan J Delwart Eric E

Veterinary microbiology 20140413 1-2

Humans keep more than 80 million cats worldwide, ensuring frequent exposure to their viruses. Despite such interactions the enteric virome of cats remains poorly understood. We analyzed a fecal sample from a single healthy cat from Portugal using viral metagenomics and detected five eukaryotic viral genomes. These viruses included a novel picornavirus (proposed genus "Sakobuvirus") and bocavirus (feline bocavirus 2), a variant of feline astrovirus 2 and sequence fragments of a highly divergent f ...[more]

PMID: 24793097

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Feline fecal virome reveals novel and prevalent enteric viruses.

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Feline fecal virome reveals novel and prevalent enteric viruses.

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