Ontology highlight
ABSTRACT:
SUBMITTER: Schmitz U
PROVIDER: S-EPMC4081082 | biostudies-literature | 2014 Jul
REPOSITORIES: biostudies-literature
Schmitz Ulf U Lai Xin X Winter Felix F Wolkenhauer Olaf O Vera Julio J Gupta Shailendra K SK
Nucleic acids research 20140529 12
MicroRNAs (miRNAs) are an integral part of gene regulation at the post-transcriptional level. Recently, it has been shown that pairs of miRNAs can repress the translation of a target mRNA in a cooperative manner, which leads to an enhanced effectiveness and specificity in target repression. However, it remains unclear which miRNA pairs can synergize and which genes are target of cooperative miRNA regulation. In this paper, we present a computational workflow for the prediction and analysis of co ...[more]