AIF downregulation and its interaction with STK3 in renal cell carcinoma.
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ABSTRACT:
SUBMITTER: Xu S
PROVIDER: S-EPMC4081115 | biostudies-literature | 2014
REPOSITORIES: biostudies-literature
Publications
AIF downregulation and its interaction with STK3 in renal cell carcinoma.
Xu Shengqiang S Wu Hongjin H Nie Huan H Yue Lei L Jiang Huadong H Xiao Sheng S Li Yu Y
PloS one 20140703 7
Apoptosis-inducing factor (AIF) plays a crucial role in caspase-independent programmed cell death by triggering chromatin condensation and DNA fragmentation. Therefore, it might be involved in cell homeostasis and tumor development. In this study, we report significant AIF downregulation in the majority of renal cell carcinomas (RCC). In a group of RCC specimens, 84% (43 out of 51) had AIF downregulation by immunohistochemistry stain. Additional 10 kidney tumors, including an oxyphilic adenoma, ...[more]
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