Ontology highlight
ABSTRACT:
SUBMITTER: Yu P
PROVIDER: S-EPMC4081639 | biostudies-literature | 2014 Jun
REPOSITORIES: biostudies-literature
Bioinformatics (Oxford, England) 20140211 11
The Dirichlet-multinomial (DMN) distribution is a fundamental model for multicategory count data with overdispersion. This distribution has many uses in bioinformatics including applications to metagenomics data, transctriptomics and alternative splicing. The DMN distribution reduces to the multinomial distribution when the overdispersion parameter ψ is 0. Unfortunately, numerical computation of the DMN log-likelihood function by conventional methods results in instability in the neighborhood of ...[more]