Ontology highlight
ABSTRACT:
SUBMITTER: Ferrajoli A
PROVIDER: S-EPMC4082321 | biostudies-literature | 2008 Jun
REPOSITORIES: biostudies-literature
Ferrajoli Alessandra A Lee Bang-Ning BN Schlette Ellen J EJ O'Brien Susan M SM Gao Hui H Wen Sijin S Wierda William G WG Estrov Zeev Z Faderl Stefan S Cohen Evan N EN Li Changping C Reuben James M JM Keating Michael J MJ
Blood 20080311 11
This study investigated the activity of lenalidomide in patients with relapsed/refractory chronic lymphocytic leukemia (CLL). Lenalidomide was given at 10 mg daily with dose escalation up to 25 mg daily. Three patients (7%) achieved a complete response (CR), one a nodular partial remission, and 10 patients a partial remission (PR), for an overall response (OR) rate of 32%. Treatment with lenalidomide was associated with an OR rate of 31% in patients with 11q or 17p deletion, of 24% in patients w ...[more]