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Targeting mitochondrial DNA with a platinum-based anticancer agent.

ABSTRACT: An analog of the anticancer drug cisplatin (mtPt) was delivered to mitochondria of human cells using a peptide specifically targeting this organelle. mtPt induces apoptosis without damaging nuclear DNA, indicating that mtDNA damage is sufficient to mediate the activity of a platinum-based chemotherapeutic. This study demonstrates the specific delivery of a platinum drug to mitochondria and investigates the effects of directing this agent outside the nucleus.

SUBMITTER: Wisnovsky SP

PROVIDER: S-EPMC4082333 | biostudies-literature | 2013 Nov

REPOSITORIES: biostudies-literature

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Targeting mitochondrial DNA with a platinum-based anticancer agent.

Wisnovsky Simon P SP Wilson Justin J JJ Radford Robert J RJ Pereira Mark P MP Chan Maria R MR Laposa Rebecca R RR Lippard Stephen J SJ Kelley Shana O SO

Chemistry & biology 20131031 11

An analog of the anticancer drug cisplatin (mtPt) was delivered to mitochondria of human cells using a peptide specifically targeting this organelle. mtPt induces apoptosis without damaging nuclear DNA, indicating that mtDNA damage is sufficient to mediate the activity of a platinum-based chemotherapeutic. This study demonstrates the specific delivery of a platinum drug to mitochondria and investigates the effects of directing this agent outside the nucleus. ...[more]

PMID: 24183971

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