Validation study of genes with hypermethylated promoter regions associated with prostate cancer recurrence.

ABSTRACT:

Background

One challenge in prostate cancer is distinguishing indolent from aggressive disease at diagnosis. DNA promoter hypermethylation is a frequent epigenetic event in prostate cancer, but few studies of DNA methylation in relation to features of more aggressive tumors or prostate cancer recurrence have been completed.

Methods

We used the Infinium HumanMethylation450 BeadChip to assess DNA methylation in tumor tissue from 407 patients with clinically localized prostate cancer who underwent radical prostatectomy. Recurrence status was determined by follow-up patient surveys, medical record review, and linkage with the Surveillance, Epidemiology, and End Results (SEER) registry. The methylation status of 14 genes for which promoter hypermethylation was previously correlat

SUBMITTER: Stott-Miller M 

PROVIDER: S-EPMC4082437 | biostudies-literature | 2014 Jul

REPOSITORIES: biostudies-literature