Ontology highlight
ABSTRACT:
SUBMITTER: Nelson DM
PROVIDER: S-EPMC4082585 | biostudies-literature | 2014 Jun
REPOSITORIES: biostudies-literature
Nelson David M DM McBryan Tony T Jeyapalan Jessie C JC Sedivy John M JM Adams Peter D PD
Age (Dordrecht, Netherlands) 20140320 3
Cellular senescence is a stable proliferation arrest associated with an altered secretory pathway, the senescence-associated secretory phenotype. However, cellular senescence is initiated by diverse molecular triggers, such as activated oncogenes and shortened telomeres, and is associated with varied and complex physiological endpoints, such as tumor suppression and tissue aging. The extent to which distinct triggers activate divergent modes of senescence that might be associated with different ...[more]