Ontology highlight
ABSTRACT:
SUBMITTER: Schaefer A
PROVIDER: S-EPMC4083384 | biostudies-literature | 2014 Jul
REPOSITORIES: biostudies-literature
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 20140430 7
Cerebral small vessel disease, mainly characterized by white matter lesions and lacunes, has a high clinical impact as it leads to vascular dementia. Recent studies have shown that this disease impairs frontoparietal networks. Here, we apply resting-state magnetic resonance imaging and data-driven whole-brain imaging analysis methods (eigenvector centrality) to investigate changes of the functional connectome in early small vessel disease. We show reduced connectivity in frontoparietal networks, ...[more]