Ontology highlight
ABSTRACT:
SUBMITTER: Goldstone DC
PROVIDER: S-EPMC4084454 | biostudies-literature | 2014 Jul
REPOSITORIES: biostudies-literature
Goldstone David C DC Walker Philip A PA Calder Lesley J LJ Coombs Peter J PJ Kirkpatrick Joshua J Ball Neil J NJ Hilditch Laura L Yap Melvyn W MW Rosenthal Peter B PB Stoye Jonathan P JP Taylor Ian A IA
Proceedings of the National Academy of Sciences of the United States of America 20140616 26
Restriction factors (RFs) form important components of host defenses to retroviral infection. The Fv1, Trim5α, and TrimCyp RFs contain N-terminal dimerization and C-terminal specificity domains that target assembled retroviral capsid (CA) proteins enclosing the viral core. However, the molecular detail of the interaction between RFs and their CA targets is unknown. Therefore, we have determined the crystal structure of the B-box and coiled-coil (BCC) region from Trim5α and used small-angle X-ray ...[more]