Ontology highlight
ABSTRACT:
SUBMITTER: O'Sullivan T
PROVIDER: S-EPMC4084720 | biostudies-literature | 2014 May
REPOSITORIES: biostudies-literature
O'Sullivan Timothy T Saddawi-Konefka Robert R Gross Emilie E Tran Miller M Mayfield Stephen P SP Ikeda Hiroaki H Bui Jack D JD
Cell reports 20140501 4
The process of cancer immunoediting generates a repertoire of cancer cells that can persist in immune-competent hosts. In its most complex form, this process begins with the elimination of highly immunogenic unedited tumor cells followed by the escape of less immunogenic edited cells. Although edited tumors can release immunosuppressive factors, it is unknown whether unedited tumors produce cytokines that enhance antitumor function. Utilizing gene microarray analysis, we found the cytokine inter ...[more]