Ontology highlight
ABSTRACT:
SUBMITTER: LeDuc RD
PROVIDER: S-EPMC4084843 | biostudies-literature | 2014 Jul
REPOSITORIES: biostudies-literature
LeDuc Richard D RD Fellers Ryan T RT Early Bryan P BP Greer Joseph B JB Thomas Paul M PM Kelleher Neil L NL
Journal of proteome research 20140612 7
The automated processing of data generated by top down proteomics would benefit from improved scoring for protein identification and characterization of highly related protein forms (proteoforms). Here we propose the "C-score" (short for Characterization Score), a Bayesian approach to the proteoform identification and characterization problem, implemented within a framework to allow the infusion of expert knowledge into generative models that take advantage of known properties of proteins and to ...[more]