Ontology highlight
ABSTRACT:
SUBMITTER: Huang P
PROVIDER: S-EPMC4084855 | biostudies-literature | 2014 Jun
REPOSITORIES: biostudies-literature
Huang Ping P Schulz Tim J TJ Beauvais Ariane A Tseng Yu-Hua YH Gussoni Emanuela E
Nature communications 20140605
Developing human muscle contains inter-myofibre progenitors expressing Bmp-receptor 1a (Bmpr1a) and Myf5 that respond to stimulation with Bmp4. Here we ablate Bmpr1a in Myf5- and MyoD-expressing cells in vivo. Mutant mice reveal increased intramuscular fat and reduced myofibre size in selected muscles, or following muscle injury. Myo-endothelial progenitors are the most affected cell type: clonal studies demonstrate that ablation of Bmpr1a in myo-endothelial cells results in decreased myogenic a ...[more]