Ontology highlight
ABSTRACT:
SUBMITTER: Yanagiya A
PROVIDER: S-EPMC4085128 | biostudies-literature | 2012 Jun
REPOSITORIES: biostudies-literature
Yanagiya Akiko A Suyama Eigo E Adachi Hironori H Svitkin Yuri V YV Aza-Blanc Pedro P Imataka Hiroaki H Mikami Satoshi S Martineau Yvan Y Ronai Ze'ev A ZA Sonenberg Nahum N
Molecular cell 20120510 6
Translational control of gene expression plays a key role in many biological processes. Consequently, the activity of the translation apparatus is under tight homeostatic control. eIF4E, the mRNA 5' cap-binding protein, facilitates cap-dependent translation and is a major target for translational control. eIF4E activity is controlled by a family of repressor proteins, termed 4E-binding proteins (4E-BPs). Here, we describe the surprising finding that despite the importance of eIF4E for translatio ...[more]