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DOTS-Finder: a comprehensive tool for assessing driver genes in cancer genomes.

ABSTRACT: A key challenge in the analysis of cancer genomes is the identification of driver genes from the vast number of mutations present in a cohort of patients. DOTS-Finder is a new tool that allows the detection of driver genes through the sequential application of functional and frequentist approaches, and is specifically tailored to the analysis of few tumor samples. We have identified driver genes in the genomic data of 34 tumor types derived from existing exploratory projects such as The Cancer Genome Atlas and from studies investigating the usefulness of genomic information in the clinical settings. DOTS-Finder is available at https://cgsb.genomics.iit.it/wiki/projects/DOTS-Finder/.

SUBMITTER: Melloni GE

PROVIDER: S-EPMC4085541 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature

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DOTS-Finder: a comprehensive tool for assessing driver genes in cancer genomes.

Melloni Giorgio Em GE Ogier Alessandro Ge AG de Pretis Stefano S Mazzarella Luca L Pelizzola Mattia M Pelicci Pier Giuseppe PG Riva Laura L

Genome medicine 20140610 6

A key challenge in the analysis of cancer genomes is the identification of driver genes from the vast number of mutations present in a cohort of patients. DOTS-Finder is a new tool that allows the detection of driver genes through the sequential application of functional and frequentist approaches, and is specifically tailored to the analysis of few tumor samples. We have identified driver genes in the genomic data of 34 tumor types derived from existing exploratory projects such as The Cancer G ...[more]

PMID: 25690659

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