Ontology highlight
ABSTRACT:
SUBMITTER: Cordova-Sintjago TC
PROVIDER: S-EPMC4085681 | biostudies-literature | 2012 Jun
REPOSITORIES: biostudies-literature
Cordova-Sintjago Tania C TC Fang Lijuan L Bruysters Martijn M Leurs Rob R Booth Raymond G RG
Journal of chemical and pharmaceutical research 20120601 6
The human histamine H<sub>1</sub> G-protein coupled receptor (GPCR) is an important drug target for inflammatory, sleep, and other neuropsychiatric disorders. To delineate molecular determinants for ligand binding for drug discovery purposes, human H<sub>1</sub> receptor models were built by homology to the crystal structure of the human β<sub>2</sub> adrenoceptor (β<sub>2</sub>AR) and from the recently reported crystal structure of the human H<sub>1</sub> receptor complex with doxepin at 3.1 Å ...[more]