Ontology highlight
ABSTRACT:
SUBMITTER: Ensminger M
PROVIDER: S-EPMC4085701 | biostudies-literature | 2014 Jul
REPOSITORIES: biostudies-literature
Ensminger Michael M Iloff Lucie L Ebel Christian C Nikolova Teodora T Kaina Bernd B Lӧbrich Markus M
The Journal of cell biology 20140630 1
Exposures that methylate DNA potently induce DNA double-strand breaks (DSBs) and chromosomal aberrations, which are thought to arise when damaged bases block DNA replication. Here, we demonstrate that DNA methylation damage causes DSB formation when replication interferes with base excision repair (BER), the predominant pathway for repairing methylated bases. We show that cells defective in the N-methylpurine DNA glycosylase, which fail to remove N-methylpurines from DNA and do not initiate BER, ...[more]