Ontology highlight
ABSTRACT:
SUBMITTER: Han Y
PROVIDER: S-EPMC4085768 | biostudies-literature | 2014 Jul
REPOSITORIES: biostudies-literature
Han Yan Y Gao Xiangwei X Liu Botao B Wan Ji J Zhang Xingqian X Qian Shu-Bing SB
Cell research 20140606 7
The journey of a newly synthesized polypeptide starts in the peptidyltransferase center of the ribosome, from where it traverses the exit tunnel. The interior of the ribosome exit tunnel is neither straight nor smooth. How the ribosome dynamics in vivo is influenced by the exit tunnel is poorly understood. Genome-wide ribosome profiling in mammalian cells reveals elevated ribosome density at the start codon and surprisingly the downstream 5th codon position as well. We found that the highly focu ...[more]