Ontology highlight
ABSTRACT:
SUBMITTER: Zhao WH
PROVIDER: S-EPMC4086240 | biostudies-literature | 2013 Feb
REPOSITORIES: biostudies-literature
Zhao Wei-Hua WH Hu Zhi-Qing ZQ
Critical reviews in microbiology 20120615 1
CTX-M enzymes, the plasmid-mediated cefotaximases, constitute a rapidly growing family of extended-spectrum β-lactamases (ESBLs) with significant clinical impact. CTX-Ms are found in at least 26 bacterial species, particularly in Escherichia coli, Klebsiella pneumoniae and Proteus mirabilis. At least 109 members in CTX-M family are identified and can be divided into seven clusters based on their phylogeny. CTX-M-15 and CTX-M-14 are the most dominant variants. Chromosome-encoded intrinsic cefotax ...[more]