Ontology highlight
ABSTRACT:
SUBMITTER: Hwang PM
PROVIDER: S-EPMC4086305 | biostudies-literature | 2001 Oct
REPOSITORIES: biostudies-literature
Hwang P M PM Bunz F F Yu J J Rago C C Chan T A TA Murphy M P MP Kelso G F GF Smith R A RA Kinzler K W KW Vogelstein B B
Nature medicine 20011001 10
Loss of p53 gene function, which occurs in most colon cancer cells, has been shown to abolish the apoptotic response to 5-fluorouracil (5-FU). To identify genes downstream of p53 that might mediate these effects, we assessed global patterns of gene expression following 5-FU treatment of isogenic cells differing only in their p53 status. The gene encoding mitochondrial ferredoxin reductase (protein, FR; gene, FDXR) was one of the few genes significantly induced by p53 after 5-FU treatment. The FR ...[more]