Tracking genomic cancer evolution for precision medicine: the lung TRACERx study.
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ABSTRACT:
SUBMITTER: Jamal-Hanjani M
PROVIDER: S-EPMC4086714 | biostudies-literature | 2014 Jul
REPOSITORIES: biostudies-literature
Publications
Tracking genomic cancer evolution for precision medicine: the lung TRACERx study.
Jamal-Hanjani Mariam M Hackshaw Alan A Ngai Yenting Y Shaw Jacqueline J Dive Caroline C Quezada Sergio S Middleton Gary G de Bruin Elza E Le Quesne John J Shafi Seema S Falzon Mary M Horswell Stuart S Blackhall Fiona F Khan Iftekhar I Janes Sam S Nicolson Marianne M Lawrence David D Forster Martin M Fennell Dean D Lee Siow-Ming SM Lester Jason J Kerr Keith K Muller Salli S Iles Natasha N Smith Sean S Murugaesu Nirupa N Mitter Richard R Salm Max M Stuart Aengus A Matthews Nik N Adams Haydn H Ahmad Tanya T Attanoos Richard R Bennett Jonathan J Birkbak Nicolai Juul NJ Booton Richard R Brady Ged G Buchan Keith K Capitano Arrigo A Chetty Mahendran M Cobbold Mark M Crosbie Philip P Davies Helen H Denison Alan A Djearman Madhav M Goldman Jacki J Haswell Tom T Joseph Leena L Kornaszewska Malgorzata M Krebs Matthew M Langman Gerald G MacKenzie Mairead M Millar Joy J Morgan Bruno B Naidu Babu B Nonaka Daisuke D Peggs Karl K Pritchard Catrin C Remmen Hardy H Rowan Andrew A Shah Rajesh R Smith Elaine E Summers Yvonne Y Taylor Magali M Veeriah Selvaraju S Waller David D Wilcox Ben B Wilcox Maggie M Woolhouse Ian I McGranahan Nicholas N Swanton Charles C
PLoS biology 20140708 7
The importance of intratumour genetic and functional heterogeneity is increasingly recognised as a driver of cancer progression and survival outcome. Understanding how tumour clonal heterogeneity impacts upon therapeutic outcome, however, is still an area of unmet clinical and scientific need. TRACERx (TRAcking non-small cell lung Cancer Evolution through therapy [Rx]), a prospective study of patients with primary non-small cell lung cancer (NSCLC), aims to define the evolutionary trajectories o ...[more]
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