Ontology highlight
ABSTRACT:
SUBMITTER: Biteau B
PROVIDER: S-EPMC4086754 | biostudies-literature | 2014 Jun
REPOSITORIES: biostudies-literature
Biteau Benoît B Jasper Heinrich H
Cell reports 20140612 6
In order to maintain tissue homeostasis, cell fate decisions within stem cell lineages have to respond to the needs of the tissue. This coordination of lineage choices with regenerative demand remains poorly characterized. Here, we identify a signal from enteroendocrine cells (EEs) that controls lineage specification in the Drosophila intestine. We find that EEs secrete Slit, a ligand for the Robo2 receptor in intestinal stem cells (ISCs) that limits ISC commitment to the endocrine lineage, esta ...[more]