OCTNs: will the real IBD5 gene please stand up?
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ABSTRACT:
SUBMITTER: Silverberg MS
PROVIDER: S-EPMC4087460 | biostudies-literature | 2006 Jun
REPOSITORIES: biostudies-literature
Publications
OCTNs: will the real IBD5 gene please stand up?
World journal of gastroenterology 20060601 23
Crohn's disease and ulcerative colitis are inflammatory disorders of the gastrointestinal tract with a substantial heritable component. The IBD5 region on chromosome 5q31 is one of only two loci widely confirmed to be associated with Crohn's disease in multiple independent cohorts. Although many populations have demonstrated association with IBD5, there remains uncertainty as to the causal variant within the region. A recent report identified polymorphisms in SLC22A4 (OCTN1) and SLC22A5 (OCTN2) ...[more]
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