Unknown

Dataset Information

0

Lactase non-persistence and milk consumption in Estonia.


ABSTRACT: AIM:To define the frequency of the C/T-13910 variant associated with lactase persistence/non-persistence trait and to analyze the milk consumption of lactase non-persistent subjects in Estonia. METHODS:We genotyped 355 Estonians by polymerase chain reaction and direct sequencing. Milk consumption was analyzed by a questionnaire, specially developed to analyze milk consumption and abdominal complaints. RESULTS:The frequency of the genotype of the C/C-13910 (lactase non-persistence) was found to be 24.8% in native Estonians. No other single nucleotide polymorphisms covering the region of 400 bp adjacent to the C/T-13910 variant were found. Lactase non-persistence subjects were found to consume less milk than lactase persistence subjects. CONCLUSION:The frequency of lactase non-persistence defined by the C/C-13910 genotype confirms the results of the previous studies based on indirect methods of determining hypolactasia. Milk consumption of lactase non-persistence subjects is consistent with previously reported figures of adult-type hypolactasia in Estonia. However, lactase non-persistence does not prevent the intake of milk in many adults.

SUBMITTER: Lember M 

PROVIDER: S-EPMC4087492 | biostudies-literature | 2006 Dec

REPOSITORIES: biostudies-literature

altmetric image

Publications

Lactase non-persistence and milk consumption in Estonia.

Lember Margus M   Torniainen Suvi S   Kull Mart M   Kallikorm Riina R   Saadla Peeter P   Rajasalu Tarvo T   Komu Hanna H   Järvelä Irma I  

World journal of gastroenterology 20061201 45


<h4>Aim</h4>To define the frequency of the C/T-13910 variant associated with lactase persistence/non-persistence trait and to analyze the milk consumption of lactase non-persistent subjects in Estonia.<h4>Methods</h4>We genotyped 355 Estonians by polymerase chain reaction and direct sequencing. Milk consumption was analyzed by a questionnaire, specially developed to analyze milk consumption and abdominal complaints.<h4>Results</h4>The frequency of the genotype of the C/C-13910 (lactase non-persi  ...[more]

Similar Datasets

| S-EPMC4495257 | biostudies-literature
| S-EPMC3287141 | biostudies-literature
| S-EPMC8652079 | biostudies-literature
| S-EPMC8073975 | biostudies-literature
| S-EPMC7325051 | biostudies-literature
| S-EPMC6115808 | biostudies-literature
| S-EPMC7258741 | biostudies-literature
2016-03-25 | E-GEOD-69979 | biostudies-arrayexpress
2016-03-25 | GSE69979 | GEO
| S-EPMC3417695 | biostudies-literature