Ontology highlight
ABSTRACT:
SUBMITTER: Treton X
PROVIDER: S-EPMC4090121 | biostudies-literature | 2014
REPOSITORIES: biostudies-literature
Tréton Xavier X Pedruzzi Eric E Guichard Cécile C Ladeiro Yannick Y Sedghi Shirin S Vallée Mélissa M Fernandez Neike N Bruyère Emilie E Woerther Paul-Louis PL Ducroc Robert R Montcuquet Nicolas N Freund Jean-Noel JN Van Seuningen Isabelle I Barreau Frédérick F Marah Assiya A Hugot Jean-Pierre JP Cazals-Hatem Dominique D Bouhnik Yoram Y Daniel Fanny F Ogier-Denis Eric E
PloS one 20140709 7
Ulcerative colitis (UC) is a chronic inflammatory bowel disease affecting the rectum which progressively extents. Its etiology remains unknown and the number of treatments available is limited. Studies of UC patients have identified an unbalanced endoplasmic reticulum (ER) stress in the non-inflamed colonic mucosa. Animal models with impaired ER stress are sensitive to intestinal inflammation, suggesting that an unbalanced ER stress could cause inflammation. However, there are no ER stress-regul ...[more]