Ontology highlight
ABSTRACT:
SUBMITTER: Gharpure KM
PROVIDER: S-EPMC4090269 | biostudies-literature | 2014 Jul
REPOSITORIES: biostudies-literature
Gharpure Kshipra M KM Chu Kevin S KS Bowerman Charles J CJ Miyake Takahito T Pradeep Sunila S Mangala Selanere L SL Han Hee-Dong HD Rupaimoole Rajesha R Armaiz-Pena Guillermo N GN Rahhal Tojan B TB Wu Sherry Y SY Luft J Christopher JC Napier Mary E ME Lopez-Berestein Gabriel G DeSimone Joseph M JM Sood Anil K AK
Molecular cancer therapeutics 20140422 7
The purpose of this study was to investigate the antitumor effects of a combination of metronomic doses of a novel delivery vehicle, PLGA-PRINT nanoparticles containing docetaxel, and antiangiogenic mEZH2 siRNA incorporated into chitosan nanoparticles. In vivo dose-finding studies and therapeutic experiments were conducted in well-established orthotopic mouse models of epithelial ovarian cancer. Antitumor effects were determined on the basis of reduction in mean tumor weight and number of metast ...[more]