Unknown

Dataset Information

0

High-resolution reduced field of view diffusion tensor imaging using spatially selective RF pulses.


ABSTRACT:

Purpose

Diffusion tensor imaging (DTI) plays a vital role in identifying white matter fiber bundles. Achievable imaging resolution and imaging time demands remain the major challenges in detecting small fiber bundles with current clinical DTI sequences.

Methods

A novel reduced field of view ultra-high-resolution DTI technique named eZOOM (elliptically refocused zonally oblique multislice) was developed. A small circular disk was imaged using spatially selective radiofrequency (RF) pulses, reducing the imaging matrix size. The frequency profile of the spectral-spatial refocusing RF pulse provided intrinsic fat suppression, eliminating the need for fat saturation pulses.

Results

Multislice DTI at a resolution of 0.35 × 0.35 mm in a celery fiber phantom was successfully performed by scanning an 8-cm field of view at 3T. An adequate diffusion-to-noise ratio (DNR >20) was achieved for a 25-min acquisition using a direct-sampling RF receiver. Human subjects (n = 7) were scanned at resolutions of 0.47 × 0.47 mm having a DNR <20 within a 75-min scanning time, requiring further enhancements to increase the signal-to-noise ratio.

Conclusions

The new eZOOM-DTI method offers multislice DTI at ultra-high imaging resolutions substantially exceeding those available with current echo-planar DTI techniques. Parallel and fast spin echo methods can be combined with eZOOM to improve SNR and DNR in humans.

SUBMITTER: Gaggl W 

PROVIDER: S-EPMC4090294 | biostudies-literature | 2014 Dec

REPOSITORIES: biostudies-literature

altmetric image

Publications

High-resolution reduced field of view diffusion tensor imaging using spatially selective RF pulses.

Gaggl Wolfgang W   Jesmanowicz Andrzej A   Prost Robert W RW  

Magnetic resonance in medicine 20140107 6


<h4>Purpose</h4>Diffusion tensor imaging (DTI) plays a vital role in identifying white matter fiber bundles. Achievable imaging resolution and imaging time demands remain the major challenges in detecting small fiber bundles with current clinical DTI sequences.<h4>Methods</h4>A novel reduced field of view ultra-high-resolution DTI technique named eZOOM (elliptically refocused zonally oblique multislice) was developed. A small circular disk was imaged using spatially selective radiofrequency (RF)  ...[more]

Similar Datasets

| S-EPMC10240017 | biostudies-literature
| S-EPMC8568630 | biostudies-literature
| S-EPMC9481036 | biostudies-literature
| S-EPMC5593980 | biostudies-literature
| S-EPMC9798222 | biostudies-literature
| S-EPMC11608938 | biostudies-literature
| S-EPMC5152949 | biostudies-literature
| S-EPMC9578148 | biostudies-literature
| S-EPMC7965571 | biostudies-literature
| S-EPMC8338815 | biostudies-literature