Significant association between TAP2 polymorphisms and rheumatoid arthritis: a meta-analysis.

ABSTRACT: Rheumatoid arthritis (RA) is a severe chronic immune mediated inflammatory disease that has been shown to be associated with human leukocyte antigen (HLA) loci. The transporter associated with antigen processing 2 (TAP2) has been identified to play an important role in the HLA-associated diseases and immune response. The goal of our meta-analysis was to summarize the contribution of TAP2 polymorphisms to the risk of RA.Meta-analyses were performed between RA and 3 TAP2 coding polymorphisms that comprised TAP2-379Ile?>?Val (rs1800454), TAP2-565Ala?>?Thr (rs2228396) and TAP2-665Thr?>?Ala (rs241447). The meta-analyses were involved with 9 studies (24 individual studies) among 973 cases and 965 controls.Meta-analyses showed that TAP2-379Ile allele was significantly associated with an increased risk of RA (p?=?0.0002, odds ratio (OR)?=?1.44, 95% confidence interval (CI)?=?1.18-1.74). This association was further shown only in the dominant model (p?=?0.006, OR?=?1.59, 95% CI?=?1.14-2.22). Subgroup analyses by ethnicity revealed that the association of TAP2-379Ile was significant in Asians (p?=?0.03, OR?=?1.38, 95% CI?=?1.04-1.83). In addition, another significant association of TAP2-565Thr allele with RA was observed in Europeans (p?=?0.002, OR?=?1.62, 95% CI?=?1.20-2.20).Our meta-analyses suggested that TAP2-379Ile allele was significantly associated with a 59% increased risk in the dominant effect model. Subgroup analyses by ethnicity showed that TAP2-379-Ile increased the risk of RA by 38% in Asians and TAP2-565Thr increased the risk of RA by 38% in Europeans.The virtual slide(s) for this article can be found here: http://www.diagnosticpathology.diagnomx.eu/vs/2097080313124700.

SUBMITTER: Dai D 

PROVIDER: S-EPMC4090395 | biostudies-literature | 2014 Jun

REPOSITORIES: biostudies-literature